Our environmental and archaeological research involves the application of mass spectrometry and separation science approaches to identify a wide range of biomarkers. We have developed new methods for compound-specific stable isotope analysis and applied these in a range of areas including palaeodietary reconstruction, plant proteomics and aquatic biology. We have also been involved in developing new methods for compound-specific radiocarbon dating in particular applied in archaeology where our methods for hydroxyproline dating have helped secure the earliest dates for human occupations and migration in Europe. We also continue to explore the chemistry of artefacts through residue analysis, particularly using 'omics' techniques providing evidence for material use and manufacture.