Systems Chemistry, Biology and Medicine

We use 'systems science’ approaches to explore how chemical and biological systems are formed from their constituent interacting parts. In 'systems chemistry' we study the interacting networks of molecules which together perform a function or possess emergent properties: a famous example is abiogenesis (how life began). 'Systems biology' looks into how DNA, RNA, proteins and metabolites interact within cells, tissues and whole organisms, to create a complex functioning biological organism. 'Systems medicine' examines the human body as an integrated system, considering how biochemical, physiological and environmental interactions play a part in our health.

Although a reductionist approach is often successful at identifying the constituent parts of a complex system, it often falls short when trying to reveal how such parts work together to create a multi-system functional unit. By comprehensive profiling of molecular landscapes, we hope to reveal such interactions and gain new insights into the basic processes of life.

Chemometrics and bioinformatics

We have a passion for developing and utilising new ways to understand our data. We employ chemometrics and bioinformatics to sift through and make sense of the complex genomics, transcriptomics, proteomics, and metabolomics datasets we generate to gain a holistic view of the systems we study. We incorporate machine learning for pattern recognition, data mining to uncover hidden information, and data visualization tools that help us interact and intuitively understand our results. Through such cutting-edge approaches, we aim to transform raw data into meaningful insights that can advance scientific discovery and understanding.

The microbiome and antimicrobial resistance

The microbiome, a rich source of nutrients within the human body and has emerged as an important mediator of our health status. Recent insights reveal that small molecules produced by microbes in the gut can profoundly influence host biology. We are actively investigating which molecules are important to understand the mechanisms behind their action. Additionally, we are exploring bacterial metabolism and how energy metabolism in particular can impact the efficacy of antibiotic treatments. We are interested in exploring how combination therapies that interact with metabolic processes can extend the effectiveness of existing antibiotics.

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Selected publications