Chemistry in Cells

Our research explores chemical processes within cells, tissues, and whole organisms to understand how changes in genes and the environment impact life at the molecular level. We use a range of advanced methods to study metabolites, proteins RNA and DNA to uncover how these perturbations affect biological systems. Our aim is to enhance our knowledge of key biological processes, paving the way for early disease detection, drug discovery and new treatments to transform patient care.

Mutations in metabolic enzymes are found in various types of cancer, with alterations in isocitrate dehydrogenase (IDH1 and IDH2) amongst the most prevalent. These mutations often result in significant changes to the metabolism of cancer cells, offering insights into how cancer cells proliferate, evade the immune system and potential new targets for cancer therapies. Achieving a detailed understanding of the molecular mechanisms involved in cancer development and progression is crucial for creating effective treatments. Our research is dedicated to uncovering these mechanistic insights, identifying potential new drug targets and the effects of new treatments on healthy and disease cells.

To study molecular mechanisms, we use tissue culture techniques to create models that simulate specific cell types, disease models, genetic mutations or treatment scenarios employing a broad spectrum of primary and immortalized cell lines. For example, we use cutting-edge methods, including viral transduction and CRISPR-Cas9 gene editing, to introduce mutations and study their effects. These approaches allow us to dissect the cellular and molecular mechanisms underlying health and disease processes, providing valuable insights that drive the development of innovative therapies. We also analyse samples taken directly from organisms and patients, including tissues and biofluids, to identify biomarkers of disease and early detection, conduct clinical studies and understand molecular processes in a whole organism context.

Chemistry in Cells

Investigating metabolic processes in cancer cells

From laboratory to clinic

Selected publications