IC-MS can be used to separate, identify and quantify a very wide range of ionisable compounds in complex samples, including those from inorganic, organic, environmental and biological origins, and is currently being applied in areas including environmental studies, forensics, medicinal chemistry, cell biology and metabolomics. IC-MS is the last of the main chromatographic types to be coupled directly with mass spectrometry, enabling exciting applications and new research capabilities, especially for life-science, environmental, and medical sciences. We have developed this technique for metabolomics application and demonstrated its capabilities for cell, tissue and bio-fluid applications (Walsby-Tickle et al., Communications Biology, 2020)
